Minor Misprint Unevenly Centered Bill
Misprints affecting centering are very common. For example, despite the poor centering on the $50 bill below, it is likely only worth about $75.
Generally speaking for a centering error to command a premium, you should be able to see two different bills due to the poor centering.
You can send us a picture of your off center misprint and we can take a look at it and give you our opinion on its value. email@example.com